Pascaline obtained in 2015 her Master's degree in Biology Health and Quality at the University of Reims Champagne-Ardenne. She possesses a background in biology, imaging and spectroscopy for biomedical application. During her Master program, she worked on the search for specific spectral biomarkers in patients with liver fibrosis and hepatocellular carcinoma.
Her thesis project is included in the MID-TECH European project under the supervision of Prof. Nick Stone in BioSpec research group at the University of Exeter. Her main objective is to use the potential of Raman and FTIR spectroscopy to evaluate more precisely the location and quantification of calcifications in breast cancer in cell lines developing calcifications and human tissues at different stages of the disease.
Louise is a PhD student who started in the BioSpec Group October 2013. She is studying surface enhanced spatially offset Raman spectroscopy (SESORS), a deep Raman technique, for intramammary carcinoma diagnosis. Louise has been producing her own gold nanoparticles (AuNPs) as well as modifying commercially bought colloids with the aim to produce the optimum signal enhancement to biocompatibility possible.
Deep Raman techniques allow for the subcutaneous identification of the biochemical composition of tissue such as malignant lesions and calcifications buried. SESORS has been found to amplify the Raman signal by many orders of magnitude. By labelling and functionalizing the AuNPs, Louise hopes to be able to measure varying expressions and locations of disease from outside of the tissue. This minimally invasive approach has the potential for sensitive cancer diagnosis allowing tailored treatment options to be considered more swiftly, making it an exciting biomedical tool.
During her time as a PhD candidate Louise has gained understanding in many different areas including organic chemistry, electronics and 3D printing; as well as developing and garnering skills in AutoDesk and website design using DreamWeaver.
Ryan Stuart Edginton
Ryan completed his MPhys undergraduate masters degree at the University of Exeter in 2013 following a two year research project investigating the mechanical impact of apoptosis on the dipole potential of the red blood cell membrane.
Now working on his PhD under Dr. Francesca Palombo as a member of Prof. Nick Stone's Biomedical Spectroscopy Labs, part of the Biomedical Physics Group at Exeter, he studies the role of hydration within the main structural proteins of the extracellular matrix, collagen and elastin. Using a dual-frequency approach applying Brillouin light scattering spectroscopy and quasi-static stress-strain testing, he probes the viscoelastic properties of the hierarchical fibre mechanics. He extracts complementary structural information spectroscopically, through the use of Raman microscopy and micro-FTIR spectroscopic imaging, with potential to apply two-photon fluorescence and single harmonic generation microscopy, developing an understanding of the biomechanics and structure-function relationships that govern the physics and chemistry of mammalian tissue.
Ryan performs the role of Outreach Officer for the Biomedical Physics Group and is a full Instructor to the Gold medal winning, University of Exeter International Genetically Engineered Machines (iGEM) team.
Leanne Fullwood is a PhD student in the Biospectroscopy group at the University of Exeter supervised by Nick Stone. She is studying ‘Raman spectroscopy for rapid diagnosis of lymphomas and metastatic lesions found in lymph nodes’. Prior to this, she studied for her undergraduate degree at the University of Central Lancashire where she continued on to complete a Master’s under the supervision of Matthew Baker. During this time she developed her desire to continue research and an interest in Raman spectroscopy. Whilst carrying out her PhD she has the opportunity of working at the biophotonics unit at Gloucester hospital where she is able to gain greater insight into the clinical side to the project and how research is implemented in healthcare settings.
Michael's background is in analytical and physical chemistry. He obtained his Bachelor’s and Master’s degree in Chemistry from the Friedrich Schiller University, Jena in cooperation with the Leibnitz Institute of Photonic Technology (IPHT). His research projects covered the application of vibrational spectroscopy and microscopy techniques for biomedical diagnostics. During his time in Jena he also taught a Master’s course and a computer course in chemometrics.
Michael joined the BioSpec group in February 2016. His PhD Project in Mid-TECH evaluates novel light sources and detectors for mid-infrared imaging on applications in histopathology. He compares state of the art technologies such as globar light sources and Mercury-Cadmium-Telluride focal plane array detectors with systems developed in Mid-TECH.
Rikke got her BSc degree in Biology from the University of Copenhagen in 2014. During her degree she worked with protein chemistry and NMR spectroscopy in SBiN lab under Dr. Birthe Brandt Kragelund . Recently she has finished a Master of Science by Research at University of Exeter, where she studied the role of the DNA damage signalling cascade in antibody diversification in the lab of Dr. Richard Chahwan (Biocatalysis Centre).
Currently she is enrolled in a PhD with primary supervisor Dr. Francesca Palombo as a member of Prof. Nick Stone's Biomedical Spectrocopy Labs within the Biophysics Group, University of Exeter. The research is conducted in collaboration with secondary supervisors Dr. Richard Chahwan and Dr. Stefano Pagliara (Biosciences, CLES). Her research is focused on FTIR imaging of live immune cells in microfluidic devices; studying chromatin changes during DNA damage and antibody diversification.