Publications

2017

Frost J, Ludeman L, Hillaby K, Gornall R, Lloyd G, Kendall C, Shore AC, Stone N. (2017) Raman spectroscopy and multivariate analysis for the non invasive diagnosis of clinically inconclusive vulval lichen sclerosus, Analyst, volume 142, no. 8, pages 1200-1206, DOI:10.1039/c6an02009g.

Old OJ, Lloyd GR, Nallala J, Isabelle M, Almond LM, Shepherd NA, Kendall CA, Shore AC, Barr H, Stone N. (2017) Rapid infrared mapping for highly accurate automated histology in Barrett's oesophagus, Analyst, volume 142, no. 8, pages 1227-1234, DOI:10.1039/c6an01871h.

Lewis AT, Gaifulina R, Isabelle M, Dorney J, Woods ML, Lloyd GR, Lau K, Rodriguez-Justo M, Kendall C, Stone N. (2017) Mirrored stainless steel substrate provides improved signal for Raman spectroscopy of tissue and cells, Journal of Raman Spectroscopy, volume 48, no. 1, pages 119-125, DOI:10.1002/jrs.4980.

2016

Frost J, Ludeman L, Hillaby K, Gornall R, Lloyd G, Kendall C, Shore AC, Stone N. (2016) Identification of cancer associated molecular changes in histologically benign vulval disease found in association with vulval squamous cell carcinoma using Fourier transform infrared spectroscopy, Analytical Methods, volume 8, no. 48, pages 8452-8460, DOI:10.1039/c6ay03059a.

Peñaranda F, Naranjo V, Kastl L, Kemper B, Lloyd GR, Nallala J, Stone N, Schnekenburger J. (2016) Multivariate classification of Fourier transform infrared hyperspectral images of skin cancer cells, European Signal Processing Conference, volume 2016-November, pages 1328-1332, DOI:10.1109/EUSIPCO.2016.7760464.

Old O, Lloyd G, Isabelle M, Kendall C, Shepherd N, Stone N, Shore A, Barr H. (2016) Detection of Barrett's Neoplasia In Oesophageal Cells Using Infrared Spectroscopy, BRITISH JOURNAL OF SURGERY, volume 103, pages 43-43.

Stone N, scott R, Rogers KD. (2016) Relationships between pathology and crystal structure in breast calcifications: an in situ X-ray diffraction study in histological sections, Nature Journal of Breast Cancer, volume 16029.

Greenwood C, Clement J, Dicken A, Evans JPO, Lyburn I, Martin RM, Rogers K, Stone N, Zioupos P. (2016) Towards new material biomarkers for fracture risk, Bone, volume 93, pages 55-63, DOI:10.1016/j.bone.2016.09.006.

Ghita A, Matousek P, Stone N. (2016) Exploring the effect of laser excitation wavelength on signal recovery with deep tissue transmission Raman spectroscopy, Analyst, volume 141, no. 20, pages 5738-5746, DOI:10.1039/c6an00490c.

Kastl L, Kemper B, Lloyd GR, Nallala J, Stone N, Naranjo V, Penaranda F, Schnekenburger J. (2016) Potential of mid IR spectroscopy in the rapid label free identification of skin malignancies, OPTICAL BIOPSY XIV: TOWARD REAL-TIME SPECTROSCOPIC IMAGING AND DIAGNOSIS, volume 9703, DOI:10.1117/12.2208897.

Nallala J, Lloyd GR, Kendall C, Barr H, Shepherd N, Stone N. (2016) Identification of GI cancers utilising rapid mid-infrared spectral imaging, OPTICAL BIOPSY XIV: TOWARD REAL-TIME SPECTROSCOPIC IMAGING AND DIAGNOSIS, volume 9703, DOI:10.1117/12.2209363.

Penaranda F, Naranjo V, Verdu R, Lloyd GR, Nallala J, Stone N. (2016) A two-step framework for the registration of HE stained and FTIR images, OPTICAL BIOPSY XIV: TOWARD REAL-TIME SPECTROSCOPIC IMAGING AND DIAGNOSIS, volume 9703, DOI:10.1117/12.2208869.

Lindsay ID, Valle S, Ward J, Stevens G, Farries M, Huot L, Brooks C, Moselund PM, Vinella RM, Abdalla M. (2016) Towards supercontinuum-driven hyperspectral microscopy in the mid-infrared, OPTICAL BIOPSY XIV: TOWARD REAL-TIME SPECTROSCOPIC IMAGING AND DIAGNOSIS, volume 9703, DOI:10.1117/12.2210836.

Seddon AB, Benson TM, Sujecki S, Abdel-Moneim N, Tang Z, Furniss D, Sojka L, Stone N, Jayakrupakar N, Lloyd GR. (2016) Towards the mid-infrared optical biopsy, OPTICAL BIOPSY XIV: TOWARD REAL-TIME SPECTROSCOPIC IMAGING AND DIAGNOSIS, volume 9703, DOI:10.1117/12.2211584.

Lloyd GR, Nallala J, Stone N. (2016) Investigating the effect of pixel size on high spatial resolution FTIR imaging for detection of colorectal cancer, OPTICAL BIOPSY XIV: TOWARD REAL-TIME SPECTROSCOPIC IMAGING AND DIAGNOSIS, volume 9703, DOI:10.1117/12.2210844.

Horsnell JD, Kendall C, Stone N. (2016) Towards the intra-operative use of Raman spectroscopy in breast cancer—overcoming the effects of theatre lighting, Lasers in Medical Science, volume 31, no. 6, pages 1143-1149, DOI:10.1007/s10103-016-1959-y.

Dicken AJ, Evans JPO, Rogers KD, Stone N, Greenwood C, Godber SX, Clement JG, Lyburn ID, Martin RM, Zioupos P. (2016) Classification of fracture and non-fracture groups by analysis of coherent X-ray scatter, Scientific Reports, volume 6, DOI:10.1038/srep29011.

Fullwood LM, Iping Petterson IE, Dudgeon AP, Lloyd GR, Kendall C, Hall C, Day JCC, Stone N. (2016) Evaluation of a multi-fibre needle Raman probe for tissue analysis, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, volume 9704, DOI:10.1117/12.2230005.

Lau K, Isabelle M, Lloyd GR, Old O, Shepherd N, Bell IM, Dorney J, Lewis A, Gaifulina R, Rodriguez-Justo M. (2016) The road map towards providing a robust Raman spectroscopy-based cancer diagnostic platform and integration into clinic, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, volume 9704, DOI:10.1117/12.2230007.

Sammon C, Schultz ZD, Kazarian S, Barr H, Goodacre R, Graham D, Baker MJ, Gardner P, Wood B, Campbell CJ. (2016) Spectral Pathology: general discussion, Faraday Discuss, volume 187, pages 155-186, DOI:10.1039/C6FD90011A.

Baker MJ, Goodacre R, Sammon C, Marques MP, Gardner P, Tipping W, Sulé-Suso J, Wood B, Byrne HJ, Hermes M. (2016) Single cell analysis/data handling: general discussion, Faraday Discuss, volume 187, pages 299-327, DOI:10.1039/C6FD90012G.

Goodacre R, Sergo V, Barr H, Sammon C, Schultz ZD, Baker MJ, Graham D, Marques MP, Sulé-Suso J, Livermore J. (2016) Clinical Spectroscopy: general discussion, Faraday Discuss, volume 187, pages 429-460, DOI:10.1039/C6FD90013E.

Goodacre R, Baker MJ, Graham D, Schultz ZD, Diem M, Marques MP, Cinque G, Vernooij R, Sulé-Suso J, Byrne HJ. (2016) Biofluids and other techniques: general discussion, Faraday Discuss, volume 187, pages 575-601, DOI:10.1039/C6FD90014C.

Vardaki MZ, Matousek P, Stone N. (2016) Characterisation of signal enhancements achieved when utilizing a photon diode in deep Raman spectroscopy of tissue, Biomedical Optics Express, volume 7, no. 6, pages 2130-2141, DOI:10.1364/BOE.7.002130.

Matousek P, Stone N. (2016) Development of deep subsurface Raman spectroscopy for medical diagnosis and disease monitoring, Chemical Society Reviews, volume 45, no. 7, pages 1794-1802, DOI:10.1039/c5cs00466g.

Gardner B, Stone N, Matousek P. (2016) Non-invasive chemically specific measurement of subsurface temperature in biological tissues using surface-enhanced spatially offset Raman spectroscopy, Faraday discussions, volume 187, pages 329-339, DOI:10.1039/c5fd00154d.

Isabelle M, Dorney J, Lewis A, Lloyd GR, Old O, Shepherd N, Rodriguez-Justo M, Barr H, Lau K, Bell I. (2016) Multi-centre Raman spectral mapping of oesophageal cancer tissues: a study to assess system transferability, Faraday Discuss, volume 187, pages 87-103, DOI:10.1039/c5fd00183h.

Iping Petterson IP, Stone NS, Day JD, Stevens O. (2016) Developing fibre optic Raman probes for applications in clinical spectroscopy, Chem. Soc. Rev, volume 45, no. 7, pages 1919-1934, DOI:10.1039/C5CS00850F.

Butler HJ, Ashton L, Bird B, Cinque G, Curtis K, Dorney J, Esmonde-White K, Fullwood NJ, Gardner B, Martin-Hirsch PL. (2016) Using Raman spectroscopy to characterize biological materials, Nature Protocols, volume 11, no. 4, pages 664-687, DOI:10.1038/nprot.2016.036.

Gardner B, Matousek P, Stone N. (2016) Temperature Spatially Offset Raman Spectroscopy (T-SORS): Subsurface Chemically Specific Measurement of Temperature in Turbid Media Using Anti-Stokes Spatially Offset Raman Spectroscopy, Analytical Chemistry, volume 88, no. 1, pages 832-837, DOI:10.1021/acs.analchem.5b03360.

Nallala J, Lloyd GR, Shepherd N, Stone N. (2016) High-resolution FTIR imaging of colon tissues for elucidation of individual cellular and histopathological features, Analyst, volume 141, no. 2, pages 630-639, DOI:10.1039/c5an01871d.

2015

Lloyd GR, Stone N. (2015) Method for identification of spectral targets in discrete frequency infrared spectroscopy for clinical diagnostics, Applied Spectroscopy, volume 69, no. 9, pages 1066-1073, DOI:10.1366/14-07677.

Barr H, Old O, Almond M, Kendall C, Rhys-Lloyd G, Shetty G, Hutchings J, Stone N. (2015) Vibrational Spectroscopy: The Solution for Immediate Medical Diagnosis, Materials Today: Proceedings, volume 2, no. 3, pages 890-893, DOI:10.1016/j.matpr.2015.06.003.

Greenwood C, Clement JG, Dicken AJ, Evans JPO, Lyburn ID, Martin RM, Rogers KD, Stone N, Adams G, Zioupos P. (2015) The micro-architecture of human cancellous bone from fracture neck of femur patients in relation to the structural integrity and fracture toughness of the tissue, Bone Reports, volume 3, pages 67-75, DOI:10.1016/j.bonr.2015.10.001.

Iping Petterson IE, Day JC, Fullwood LM, Gardner B, Stone N. (2015) Characterisation of a fibre optic Raman probe within a hypodermic needle, Anal Bioanal Chem, volume 407, no. 27, pages 8311-8320, DOI:10.1007/s00216-015-9021-7.

Kong K, Kendall C, Stone N, Notingher I. (2015) Raman spectroscopy for medical diagnostics - From in-vitro biofluid assays to in-vivo cancer detection, Advanced Drug Delivery Reviews, volume 89, pages 121-134, DOI:10.1016/j.addr.2015.03.009.

Dicken AJ, Evans JPO, Rogers KD, Stone N, Greenwood C, Godber SX, Prokopiou D, Clement JG, Lyburn ID, Martin RM. (2015) X-ray diffraction from bone employing annular and semi-annular beams, Physics in Medicine and Biology, volume 60, no. 15, pages 5803-5812, DOI:10.1088/0031-9155/60/15/5803.

Vardaki MZ, Gardner B, Stone N, Matousek P. (2015) Studying the distribution of deep Raman spectroscopy signals using liquid tissue phantoms with varying optical properties, The Analyst, volume 140, no. 15, pages 5112-5119, DOI:10.1039/c5an01118c.

Dicken AJ, Evans JPO, Rogers KD, Greenwood C, Godber SX, Prokopiou D, Stone N, Clement JG, Lyburn I, Martin RM. (2015) Energy-dispersive X-ray diffraction using an annular beam, Optics Express, volume 23, no. 10, pages 13443-13454, DOI:10.1364/OE.23.013443.

Byrne HJ, Baranska M, Puppels GJ, Stone N, Wood B, Gough KM, Lasch P, Heraud P, Sulé-Suso J, Sockalingum GD. (2015) Spectropathology for the next generation: Quo vadis?, Analyst.

Townsend D, Miljkovic M, Bird B, Lenau K, Old O, Almond M, Kendall C, Lloyd G, Shepherd N, Barr H. (2015) Infrared micro-spectroscopy for cyto-pathological classification of esophageal cells, Analyst.

Nallala J, Lloyd GR, Stone N. (2015) Evaluation of different tissue de-paraffinization procedures for infrared spectral imaging, Analyst, volume 140, no. 7, pages 2369-2375, DOI:10.1039/c4an02122c.

2014

Madami M, Fioretto D, Palombo F, Winlove CP, Edginton RS, Green E, Stone N, Caponi S. (2014) Biomechanics of fibrous proteins of the extracellular matrix.

Almond M, Old O, Hutchings J, Kendall C, Lloyd G, Stone N, Barr H. (2014) Endoscopic Raman spectroscopy enables objective diagnosis of dysplasia in the oesophagus, BRITISH JOURNAL OF SURGERY, volume 101, pages 5-5.

Almond LM, Old O, Stone N, Kendall C, Lloyd GR, Hutchings J, Horsnell J, Kallaway C, Barr H. (2014) Real-time disease detection using spectroscopic diagnosis, Biomedical Spectroscopy and Imaging, volume 3, pages 197-202, article no. 3.

Stone N, Kallaway C, Almond LM, Wood J, Hutchings J, Kendall C, Barr H. (2014) Molecular Endospectroscopic Approaches, pages 179-214, DOI:10.1002/9783527681921.ch6.

Palombo F, Winlove CP, Edginton RS, Green E, Stone N, Caponi S, Madami M, Fioretto D. (2014) Biomechanics of fibrous proteins of the extracellular matrix studied by Brillouin scattering, J R Soc Interface, volume 11, no. 101, DOI:10.1098/rsif.2014.0739.

Naranjo V, Villanueva E, Lloyd GR, Stone N, Lopez-Mir F, Alcaniz M. (2014) Stained and infrared image registration as first step for cancer detection, 2014 IEEE-EMBS International Conference on Biomedical and Health Informatics, BHI 2014, pages 420-423, DOI:10.1109/BHI.2014.6864392.

Wood JJ, Kendall C, Hutchings J, Lloyd GR, Stone N, Shepherd N, Day J, Cook TA. (2014) Evaluation of a confocal Raman probe for pathological diagnosis during colonoscopy, Colorectal Disease, volume 16, no. 9, pages 732-738, DOI:10.1111/codi.12664.

Sattlecker M, Stone N, Bessant C. (2014) Current trends in machine-learning methods applied to spectroscopic cancer diagnosis, TrAC - Trends in Analytical Chemistry, volume 59, pages 17-25, DOI:10.1016/j.trac.2014.02.016.

Old OJ, Fullwood LM, Scott R, Lloyd GR, Almond LM, Shepherd NA, Stone N, Barr H, Kendall C. (2014) Vibrational spectroscopy for cancer diagnostics, Analytical Methods, volume 6, no. 12, pages 3901-3917, DOI:10.1039/c3ay42235f.

Scott R, Kendall C, Stone N, Rogers K. (2014) Locating microcalcifications in breast histopathology sections using micro CT and XRF mapping, Analytical Methods, volume 6, no. 12, pages 3962-3966, DOI:10.1039/c3ay42158a.

Almond LM, Hutchings J, Lloyd G, Barr H, Shepherd N, Day J, Stevens O, Sanders S, Wadley M, Stone N. (2014) Endoscopic Raman spectroscopy enables objective diagnosis of dysplasia in Barrett's esophagus, Gastrointestinal Endoscopy, volume 79, no. 1, pages 37-45, DOI:10.1016/j.gie.2013.05.028.

Lloyd GR, Almond LM, Stone N, Shepherd N, Sanders S, Hutchings J, Barr H, Kendall C. (2014) Utilising non-consensus pathology measurements to improve the diagnosis of oesophageal cancer using a Raman spectroscopic probe, Analyst, volume 139, no. 2, pages 381-388, DOI:10.1039/c3an01163a.

Palombo F, Madami M, Stone N, Fioretto D. (2014) Mechanical mapping with chemical specificity by confocal Brillouin and Raman microscopy, Analyst, volume 139, pages 729-733, DOI:10.1039/C3AN02168H.

2013

Almond M, Rhys-Lloyd G, Hutchings J, Shetty G, Shepherd N, Kendall C, Stone N, Barr H. (2013) The prospects for real-time raman spectroscopy for oesophageal neoplasia, RSC Detection Science, pages 201-221.

Kallaway C, Almond LM, Barr H, Wood J, Hutchings J, Kendall C, Stone N. (2013) Advances in the clinical application of Raman spectroscopy for cancer diagnostics, Photodiagnosis and Photodynamic Therapy, volume 10, no. 3, pages 207-219, DOI:10.1016/j.pdpdt.2013.01.008.

Pijanka JK, Stone N, Rutter AV, Forsyth N, Sockalingum GD, Yang Y, Sulé-Suso J. (2013) Identification of different subsets of lung cells using Raman microspectroscopy and whole cell nucleus isolation, Analyst, volume 138, no. 17, pages 5052-5058, DOI:10.1039/c3an00968h.

Lloyd GR, Orr LE, Christie-Brown J, McCarthy K, Rose S, Thomas M, Stone N. (2013) Discrimination between benign, primary and secondary malignancies in lymph nodes from the head and neck utilising Raman spectroscopy and multivariate analysis, ANALYST, volume 138, no. 14, pages 3900-3908, DOI:10.1039/c2an36579k.

Almond LM, Hutchings J, Lloyd G, Barr H, Shepherd N, Day J, Stevens O, Sanders S, Wadley M, Stone N. (2013) Endoscopic Raman spectroscopy enables objective diagnosis of dysplasia in Barrett's esophagus, Gastrointestinal Endoscopy.

Day JCC, Stone N. (2013) A subcutaneous Raman needle probe, Applied Spectroscopy, volume 67, no. 3, pages 349-354, DOI:10.1366/12-06651.

Matousek P, Stone N. (2013) Recent advances in the development of Raman spectroscopy for deep non-invasive medical diagnosis, Journal of Biophotonics, volume 6, no. 1, pages 7-19, DOI:10.1002/jbio.201200141.