Pascaline obtained in 2015 her Master's degree in Biology Health and Quality at the University of Reims Champagne-Ardenne. She possesses a background in biology, imaging and spectroscopy for biomedical application. During her Master program, she worked on the search for specific spectral biomarkers in patients with liver fibrosis and hepatocellular carcinoma.
Her thesis project is included in the MID-TECH European project under the supervision of Prof. Nick Stone in BioSpec research group at the University of Exeter. Her main objective is to use the potential of Raman and FTIR spectroscopy to evaluate more precisely the location and quantification of calcifications in breast cancer in cell lines developing calcifications and human tissues at different stages of the disease.
Dr Priyanka Dey
Priyanka attained her PhD in Chemistry specializing in nanotechnology and optical spectroscopy, from Queensland University of Technology (QUT), Australia, in 2014 with the “Outstanding thesis award”. Since then, her research has focussed on designing and developing nanomaterial based solutions to real-life problems. This has included work in water desalination in Australia, nanoplasmonics and photonics in Munich, Germany and optical nanobiosensors for clinical and point-of-care devices in Barcelona, Spain. Her current research on the RaNT programme involves developing SERS Gold Nanostructures for Raman biodiagnostics employing a SESORS-based approach to detect cancer from within deep tissue.
Dr Alex Dudgeon
I am a research fellow in the Biomedical Spectroscopy Team in the Biophysics Group working with Prof Nick Stone at The University of Exeter. My current work on the is on the Raman needle project which is seeking to diagnose lymphomas with a fibre-optic needle on the "DOLPHIN-VIVO: Diagnosis Of LymPHoma IN VIVO" project. I am also working on a similar endoscopic Raman probe for oesophageal cancer diagnosis, the "RAPIDE: Raman Probe for In-vivo Diagnostics (during oesophageal) Endoscopy" project:
For my PhD at Durham University in Professor Colin Bain’s group, I designed and built a total-internal reflection Raman spectrometer. This technique utilises the evanescent field produced during total-internal reflection to excite molecules close to the interface. I investigated the adsorption of surfactants to the liquid-solid interface and focused on the kinetics of adsorption, obtaining isotherms and forming mono/bi-layers of various ionic and nonionic surfactants on surfaces including polyester and zeolite. A major part of the project was the design and construction of the spectrometer.
Additionally in the group, my research MSc investigated the processes by which water and surfactant solutions penetrate glass capillaries. Theoretical models (The Lucas-Washburn model, a “Young” model and an overflowing-cylinder model) were compared with our experimental data and the models were shown to be unable to account for the observed penetration rates. Instead, we considered the additional dissipation in the wedge of liquid near the three-phase contact line.
Dr Benjamin Gardener
I am currently a research fellow in the Biomedical physics group working with Professor Nick Stone on the following EPSRC research grant: A Novel Deep Raman Spectroscopy Platform for Non-Invasive in vivo Diagnosis of Breast Cancer.
This project aims to develop Raman spectroscopy as a non-invasive method for the detection and diagnosis of breast cancer. This is important as the current methods for detecting breast cancer have a high false positive rate, resulting in unrequired biopsies, and preventable patient stress. The current approaches are also limited to older patients, leaving younger patients vulnerable. Raman spectroscopy has the potential to provide quick reliable and non-invasive platform to diagnose breast cancer.
Other research interests include developing the Deep Raman approaches for characterising and monitoring a materials physical properties such as temperature non-invasively with chemical specificity at depth within objects.
I am currently also a manager for the CEMPS early career researcher network ECRN.
Dr Adrian Ghita
Adrian has a primary interest in the development of Raman spectroscopy for biomedical applications, spanning from micro-Raman examinations of live cells and tissue sections in vitro, to transmission Raman spectroscopy on larger tissue samples. He is introducing various novel photonic techniques to the traditional instrumental design of Raman spectroscopy allowing further improvement and expansion of this technique to the new fields of biomedical applications. The potential of the new emerging methods can be harnessed for the interest of new in vivo clinical applications such as breast cancer detection, which is Adrian's primary study disease.
Dr Jayakrupakar Nallala
Jayakrupakar Nallala graduated with a distinction in BSc-biotechnology from Osmania University, obtained MSc in biotechnology from Bharathidasan University and carried out initial research activities at the Center for Cellular and Molecular Biology (CCMB) and the Advanced Center for Treatment Research and Education in Cancer (ACTREC), Tata Memorial Center in India. His initial research activities involved DNA sequencing and genotyping of single nucleotide and repeat length polymorphisms in specific genes and their association with breast, and head and neck cancers.
Jayakrupakar obtained PhD from the Université de Reims Champagne-Ardenne, France during which the potentials of vibrational spectroscopy as a cancer diagnostic tool were demonstrated via the concepts of spectral histopathology and infrared spectral barcoding of colon tissue and tissue arrays.
His current research areas of interest are to exploit further the potentials of vibrational spectroscopy methods of infrared and Raman to detect the bio-molecular/bio-chemical changes in tissues and to diagnose molecular diseases especially cancer. To obtain a complete picture, Jayakrupakar intends to combine this technology with conventional clinical/pathological practices of histopathology, immunohistochemistry, etc. In the ongoing project ‘MINERVA’ funded by the European Union (FP7) (http://minerva-project.eu/) it is aimed to explore and implement the new generation infrared spectroscopic imaging technology being developed using new mid-infrared supercontinuum light sources, and new generation detectors for large scale pathology screening and to develop clinical applications of infrared spectral histopathology/cytology for improved cancer diagnostics.
Jayakrupakar is an Associate member of the Royal Society of Chemistry (RSC), an Honorary fellow at the Biophotonics Research Unit, Gloucestershire Royal Hospitals NHS Foundation Trust, United Kingdom and was a recipient of the ‘Rambhau Kulkarni Young Scientist Award’ from the Indian Association for Cancer Research (IACR), 2008.
Dr Chun-Chin Wang
Dr Chun-Chin Wang earned his M.S. in Physics and Ph.D. in Biomedical Engineering at National Taiwan University, where he applied intravital two-photon microscopy to early skin and lung cancer diagnosis. Dr. Wang briefly conducted postdoctoral work on in vivo three-photon imaging of quantum-dot-labelled brain with Prof. Chris Xu at Cornell University before moving to his current research fellow position at University of Exeter with Prof. Julian Moger and Prof. Nick Stone. While at Exeter, he has focused on the development of label-free microscopy such as stimulated Raman scattering (SRS) microscopy, which he has applied to in situ chemically-specific mapping of plant and animal tissues. He will continue to develop innovative optical spectroscopy and multimodal imaging techniques, and establish a new imaging facility dedicated to RaNT programme.