SUPPLEMENTAL VIDEO FILES

for: Generation and escape of local waves from the boundary of uncoupled cardiac tissue

• SUPPLEMENT to Fig.3. (Quick Time Movie, 3.9Mb) Experimental video file illustrating the continuous generation of target-like (or ectopic) waves and spirals within the boundary layer. The acquisition window was moved during the experiment alongside the boundary to center each event. Propagation to the inner zone is impeded by the continuous presence of the uncoupler (heptanol).
• SUPPLEMENT to Fig. 4 (Quick Time Movie, 3.9Mb) Experimental video file illustrating the distinct features of boundary spirals. An episode of the attachment of a spiral tip to an area of elevated excitability is shown. It manifests itself as an ectopic source emanating from the same area immediately after the spiral self-terminates. One can also see the shape flattening of the spiral near the boundary, due to a progressive wavelength shortening as conduction velocity sharply drops toward the inner zone. This creates an apparent “shedding” effect, when wavefronts from two or three previous spiral rotations are seen within the boundary layer.
• SUPPLEMENT to Fig.5. (MPEG4, 5.3Mb) Numerical studies: formation of local waves within a boundary layer. Activation patterns developing for the boundary with growing mean automaticity <α> (see Fig. 5 legend for details). Color coding by components: red for transmembrane voltage, green for D and and blue for gK1.
• SUPPLEMENT to Fig. 6 (MPEG4, 8.8Mb) Impact of cell heterogeneity. Mean automaticity <α> grows while the boundary is fixed in space. The coefficients of dispersion are different: δ = 0.5 for the study shown on the left and δ = 0.25 for the study shown on the right. The videos correspond to the events shown in Fig. 5A, specifically they show 100-180 sec of the simulation sequence.
• SUPPLEMENT to Fig. 8 (MPEG4, 2.7Mb) Drift of a spiral along moving boundary. Drift with pinning and then escape into the well coupled zone. The boundary moves downwards slowly at a rate of 1/6 cell/sec. The video file corresponds to the events shown in Fig. 8A (first 25 sec of the simulation sequence).
• SUPPLEMENT to Fig. 9 (MPEG4, 3.4Mb) Effect of the speed. Video on the left: boundary moves faster, spiral waves escape to the well coupled zone. Video on the right: boundary moves slower, spiral tip does not escape. In both simulations, the boundary starts moving at t=10 sec. The videos correspond to the events depicted in Fig.9, specifically they show the first 30 sec of the simulation sequence.